Natalie Springer is a friend of Karen Brewer and her friends. They are in Ms. Colman's class together. Like Karen, Natalie has blonde hair and wears glasses. Natalie is sensitive, shy, and smart.

She wears droopy socks that she constantly has to pull up. She also has a lisp, where she cannot pronounce her "s" and "z" correctly. She has a habit of snorting when she cries.She is known as being a klutz. In the Baby Sitters Little Sister series, she is known for getting sick on buses, as she did in Karen's Kite, and Karen's School Trip.

Natalie loves cats, so much in fact that in Karen's Kittens, she tries to adopt Ruby. In Karen's Kite, Natalie's grandfather dies.

Natalie has her own BSC book, Second Grade Baby.

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